RO5166017
Cat. No.：YN322135
| 产品名称: | RO5166017 |
| CAS No.: | 1048346-74-2 |
| Chemical Name: | (4S)-2-amino-N-ethyl-4,5-dihydro-N-phenyl-4-oxazolemethanamine |
| Synonyms: | RO5166017;RO-5166017 |
| 分子量: | 219.283 |
| 分子式: | C12H17N3O |
| SMILES: | CCN(C1=CC=CC=C1)C[C@H]2COC(N)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RO5166017 是具有口服活性的、跨物种的TAAR1的激动剂，其对小鼠、大鼠、人和食蟹猴的Ki值分别为1.9 nM、2.7 nM、31 nM 和 24 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Revel, F.G., Moreau, J.-L., Gainetdinov, R.R., et al.TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activityProc. Natl. Acad. Sci. USA108(20),8485-8490(2011)
Liu, J.-F., Thorn, D.A., Zhang, Y., et al.Effects of trace amine-associated receptor 1 agonists on the expression, reconsolidation, and extinction of cocaine reward memoryInt. J. Neuropsychopharmacol.19(7),pyw009(2016)
