MF-766
Cat. No.：YN322136
CAS No. ：1050656-06-8
| 产品名称: | MF-766 |
| CAS No.: | 1050656-06-8 |
| Chemical Name: | 4-[1-[[[1-[[4-(trifluoromethyl)phenyl]methyl]-1H-indol-7-yl]carbonyl]amino]cyclopropyl]-benzoic acid |
| Synonyms: | Compound 9a |
| 分子量: | 478.4625296 |
| 分子式: | C27H21F3N2O3 |
| SMILES: | O=C(C1=CC=C(C2(CC2)NC(C3=CC=CC4=C3N(CC5=CC=C(C(F)(F)F)C=C5)C=C4)=O)C=C1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MF-766 是一种高效、选择性和口服活性的EP4拮抗剂，Ki值为 0.23 nM。MF-766 在功能检测中表现为一种完整的拮抗剂，其 IC50为 1.4 nM (在 10% HS 存在时变成 1.8 nM)。MF-766 可用于癌症和炎症疾病研究。 |
| IC50和靶点: | [{name:"EP4:0.23 nM (Ki)"}] |
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| Solvent & Solubility: |
Colucci, J., Boyd, M., Berthelette, C., et al.Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory painBioorg. Med. Chem. Lett.20(12),3760-3763(2010)
Wang, Y., Cui, L., Georgiev, P., et al.Combination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cellsOncoimmunology10(1),1896643(2021)
