Glemanserin
Cat. No.：YN380322
CAS No. ：107703-78-6
| 产品名称: | Glemanserin |
| CAS No.: | 107703-78-6 |
| Chemical Name: | α-phenyl-1-(2-phenylethyl)-4-piperidinemethanol |
| Synonyms: | MDL11939 |
| 分子量: | 295.4 |
| 分子式: | C20H25NO |
| SMILES: | OC(C1CCN(CCC2=CC=CC=C2)CC1)C3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Glemanserin (MDL11939) 是有效和选择性5-HT2A受体的拮抗剂，对大鼠 5-HT2A、兔 5-HT2A和人 5-HT2A受体的Ki分别为 2.89、0.54 和 2.5 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Dudley, M.W., Wiech, N.L., Miller, F.P., et al.Pharmacological effects of MDL 11,939: A selective, centrally acting antagonist of 5-HT2 receptorsDrug Dev. Res.13(1),29-43(1988)
Wainscott, D.B., Lucaites, V.L., Kursar, J.D., et al.Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: Evidence for species differencesJ. Pharmacol. Exp. Ther.276(2),720-727(1996)
Jiang, X., Zhang, Z.-j., Zhang, S., et al.5-HT2A receptor antagonism by MDL 11,939 during inescapable stress prevents subsequent exaggeration of acoustic startle response and reduced body weight in ratsJ. Psychopharmacol.25(2),289-297(2011)
Koerner, J.E., and Dage, R.C.Antiarrhythmic and electrophysiologic effects of MDL 11,939, a novel class III antiarrhythmic agent in anesthetized dogsJ. Cardiovasc. Pharmacol.16(3),383-393(1990)
