Agomelatine-d
Cat. No.：YN322143
| 产品名称: | Agomelatine-d |
| CAS No.: | 1079389-42-6 |
| Chemical Name: | N-[2-[7-(methoxy-d3)-1-naphthalenyl]ethyl]-acetamide-2,2,2-d3 |
| Synonyms: | S-20098-d |
| 分子量: | 249.33738 |
| 分子式: | C15H11D6NO2 |
| SMILES: | O=C(C([2H])([2H])[2H])NCCC1=CC=CC2=C1C=C(OC([2H])([2H])[2H])C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Agomelatine-d6是氘标记的 Agomelatine。Agomelatine 是MT1和MT2受体的特异性激动剂。 |
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Poissonnier-Durieux, S., Ettaoussi, M., Pérès, B., et al.Synthesis of 3-phenylnaphthalenic derivatives as new selective MT2 melatoninergic ligandsBioorg. Med. Chem.16(18),8339-8348(2008)
Millan, M.J., Gobert, A., Lejeune, F., et al.The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathwaysJ. Pharmacol. Exp. Ther.306(3),954-964(2003)
Barden, N., Shink, E., Labbé, M., et al.Antidepressant action of agomelatine (S 20098) in a transgenic mouse modelProg. Neuropsychopharmacol. Biol. Psychiatry29(6),908-916(2005)
