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Azilsartan-d

Cat. No.:YN322145

  • CAS No. :1089736-73-1

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    • 产品名称: Azilsartan-d
      CAS No.: 1089736-73-1
      Chemical Name: N-(1-oxopentyl-2,2,3,3,4,4,5,5,5-d9)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine
      Synonyms:缬沙坦 D9; CGP 48933-d
      分子量:444.5735
      分子式:C24H20D9N5O3
      SMILES:O=C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])N([C@@](C(O)=O)([H])C(C)C)CC1=CC=C(C2=CC=CC=C2C3=NNN=N3)C=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Valsartan-d9是 Valsartan 氘代化合物。Valsarta 是血管紧张素 II 受体拮抗剂,有潜力用于高血压和心力衰竭的研究。
      IC50和靶点:
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    • Burnier, M.Angiotensin II type 1 receptor blockersCirculation103(6),904-912(2001)

      Munger, M.A.Use of angiotensin receptor blockers in cardiovascular protection: Current evidence and future directionsPT36(1),22-40(2011)

      Suematsu, Y., Miura, S., Goto, M., et al.LCZ696, an angiotensin receptor-neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in streptozotocin-induced diabetic miceEur. J. Heart Fail.18(4),386-393(2016)

      Irons, B.K., Tsikouris, J.P., and Thomas, A.A.The use of angiostensin receptor blockers in the treatment of chronic hear failureJ. Cardiovasc. Pharmacol.44(6),718-724(2004)

      Schiffrin, E.L.Beyond blood pressure: The endothelium and atherosclerosis progressionAm. J. Hypertens.15(10 Pt 2),115S-122S(2002)

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