PSB-603
Cat. No.：YN322147
| 产品名称: | PSB-603 |
| CAS No.: | 1092351-10-4 |
| Chemical Name: | 8-[4-[[4-(4-chlorophenyl)-1-piperazinyl]sulfonyl]phenyl]-3,9-dihydro-1-propyl-1H-purine-2,6-dione |
| Synonyms: | PSB603; PSB 603; PSB-603. |
| 分子量: | 529 |
| 分子式: | C24H25ClN6O4S |
| SMILES: | O=S(C1=CC=C(C2=NC(NC(N(CCC)C3=O)=O)=C3N2)C=C1)(N4CCN(C5=CC=C(Cl)C=C5)CC4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PSB-603 是一种有效的高选择性A2B腺苷受体拮抗剂，Ki为 0.553 nM，对人和大鼠 A1和 A2A以及人 A3受体几乎没有亲和力。 |
| IC50和靶点: | |
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Borrmann, T., Hinz, S., Bertarelli, D.C., et al.1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: Development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificityJ. Med. Chem.52(13),3994-4006(2009)
Micewicz, E.D., Khachatoorian, R., French, S.W., et al.Identification of novel small-molecule inhibitors of Zika virus infectionBioor. Med. Chem. Lett.28(3),452-458(2018)
Kaji, W., Tanaka, S., Tsukimoto, M., et al.Adenosine A2B receptor antagonist PSB603 suppresses tumor growth and metastasis by inhibiting induction of regulatory T cellsJ. Toxicol. Sci.39(2),191-198(2014)
