CYM5442
Cat. No.：YN322149
CAS No. ：1094042-01-9
| 产品名称: | CYM5442 |
| CAS No.: | 1094042-01-9 |
| Chemical Name: | 2-[[4-[5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]amino]-ethanol |
| Synonyms: | CYM 5442,CYM-5442 |
| 分子量: | 409.5 |
| 分子式: | C23H27N3O4 |
| SMILES: | CCOC1=C(OCC)C=C(C2=NC(C3=CC=CC4=C3CCC4NCCO)=NO2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CYM5442 是一种有效的，高选择性和口服活性的 鞘氨醇 1-磷酸 (S1P1) 受体激动剂，EC50为 1.35 nM。CYM5442 对 S1P2，S1P3，S1P4 和 S1P5 无活性。CYM5442 激活依赖S1P1的 p42/p44-MAPK 磷酸化。CYM5442 具有视网膜神经保护作用，并可轻松穿过中枢神经系统。 |
| IC50和靶点: | |
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Rosen, H., Stevens, R.C., Hanson, M., et al.Sphingosine-1-phosphate and its receptors: Structure, signaling, and influenceAnnu. Rev. Biochem.82,637-662(2013)
Gonzalez-Cabrera, P.J., Jo, E., Sanna, M.G., et al.Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactionsMol. Pharmacol.74(5),1308-1318(2008)
