Ro 5212773
Cat. No.：YN322156
CAS No. ：1110781-88-8
| 产品名称: | Ro 5212773 |
| CAS No.: | 1110781-88-8 |
| Chemical Name: | N-(3-ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)-benzamide |
| Synonyms: | EPPTB |
| 分子量: | 378.4 |
| 分子式: | C20H21F3N2O2 |
| SMILES: | O=C(C1=CC=C(N2CCCC2)C(C(F)(F)F)=C1)NC3=CC(OCC)=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ro 5212773 (EPPTB) 是一种有效和选择性的(TAAR1)拮抗剂(对于小鼠 TAAR1 的Ki值为 0.9 nM)，对其他 TAARs 没有显著影响。TAAR1 是一种 G 蛋白偶联受体 (GPCR)，由内源性氨基酸代谢产物非选择性激活。 |
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Bradaia, A., Trube, G., Stalder, H., et al.The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic systemProc. Natl. Acad. Sci. USA106(47),20081-20086(2009)
