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Scopolamine hydrobromide

Cat. No.:YN322165

  • CAS No. :114-49-8

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    • 产品名称: Scopolamine hydrobromide
      CAS No.: 114-49-8
      Chemical Name: (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester αS-(hydroxymethyl)-benzeneacetic acid, monohydrobromide
      Synonyms:氢溴酸东莨菪碱; Hyoscine hydrobromide; Scopine (-
      分子量:384.26492
      分子式:C17H21NO4 • HBr
      SMILES:O=C([C@H](CO)C1=CC=CC=C1)O[C@H]2C[C@H](N3C)[C@H](O4)[C@H]4[C@H]3C2
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Scopolamine hydrobromide 是高亲和力的 (nM 级别) 毒蕈碱 (muscarinic) 拮抗剂。Scopolamine 可逆抑制 5-HT3受体反应,IC50为 2.09 μM。
      IC50和靶点: [{name:"5-HT3 Receptor:2.09 μM (IC50)'}, 'mAChR']
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Ziegler, J., and Facchini, P.J.Alkaloid biosynthesis: Metabolism and traffickingAnnu. Rev. Plant Biol.59,735-769(2008)

      Woods, S., Clarke, N.N., Layfield, R., et al.5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanismsBr. J. Pharmacol.167,436-449(2012)

      Soto, E., and Vega, R.Neuropharmacology of vestibular system disordersCurr. Neuropharmacol.8(1),26-40(2010)

      Shannon, H.E., Hart, J.C., Bymaster, F.P., et al.Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in ratsJ. Pharmacol. Exp. Ther.290(2),901-907(1999)

      Grynkiewicz, G., and Gadzikowska, M.Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugsPharmacol. Rep.60(4),439-463(2008)

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