Scopolamine hydrobromide

Cat. No.：YN322165

CAS No. ：114-49-8

产品名称:	Scopolamine hydrobromide
CAS No.:	114-49-8
Chemical Name:	(1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester αS-(hydroxymethyl)-benzeneacetic acid, monohydrobromide
Synonyms:	氢溴酸东莨菪碱; Hyoscine hydrobromide; Scopine (-
分子量:	384.26492
分子式:	C17H21NO4 • HBr
SMILES:	O=C([C@H](CO)C1=CC=CC=C1)O[C@H]2C[C@H](N3C)[C@H](O4)[C@H]4[C@H]3C2
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

Select Batch:

Purity: 98%

产品描述:	Scopolamine hydrobromide 是高亲和力的 (nM 级别) 毒蕈碱 (muscarinic) 拮抗剂。Scopolamine 可逆抑制 5-HT3受体反应，IC50为 2.09 μM。
IC50和靶点:	[{name:"5-HT3 Receptor:2.09 μM (IC50)'}, 'mAChR']
In Vitro:
In Vivo:
Clinical Trial:
Solvent & Solubility:

Ziegler, J., and Facchini, P.J.Alkaloid biosynthesis: Metabolism and traffickingAnnu. Rev. Plant Biol.59,735-769(2008)
Woods, S., Clarke, N.N., Layfield, R., et al.5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanismsBr. J. Pharmacol.167,436-449(2012)
Soto, E., and Vega, R.Neuropharmacology of vestibular system disordersCurr. Neuropharmacol.8(1),26-40(2010)
Shannon, H.E., Hart, J.C., Bymaster, F.P., et al.Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in ratsJ. Pharmacol. Exp. Ther.290(2),901-907(1999)
Grynkiewicz, G., and Gadzikowska, M.Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugsPharmacol. Rep.60(4),439-463(2008)