AF-DX 384
Cat. No.：YN322174
| 产品名称: | AF-DX 384 |
| CAS No.: | 118290-26-9 |
| Chemical Name: | N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide |
| Synonyms: | |
| 分子量: | 478.62986 |
| 分子式: | C27H38N6O2 |
| SMILES: | O=C1NC(C=CC=N2)=C2N(C(NCCN3C(CN(CCC)CCC)CCCC3)=O)C4=C1C=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AF-DX 384 是 M2 和 M4 毒蕈碱乙酰胆碱受体的选择性拮抗剂 ，Ki分别为 6.03 nM 和 10 nM。AF-DX 384 可逆转老年大鼠以及东莨菪碱诱导的幼鼠在新物体识别和被动回避方面的缺陷。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Dörje, F., Wess, J., Lambrecht, G., et al.Antagonist binding profiles of five cloned human muscarinic receptor subtypesJ. Pharmacol. Exp. Ther.256(2),727-733(1991)
Vannucchi, M.G., Scali, C., Kopf, S.R., et al.Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged ratsNeuroscience79(3),837-846(1997)
