BW A868C
Cat. No.：YN322176
| 产品名称: | BW A868C |
| CAS No.: | 118675-50-6 |
| Chemical Name: | 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-4-imidazolidineheptanoic acid |
| Synonyms: | |
| 分子量: | 459.6 |
| 分子式: | C25H37N3O5 |
| SMILES: | O=C1C(CCCCCCC(O)=O)N(NCC(O)C2CCCCC2)C(N1CC3=CC=CC=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BW A868C 是一种乙内酰脲化合物，是 BW245C 结构类似物。BW A868C 是一种选择性强的竞争性前列腺素 D2 (PGD2) 拮抗剂。BW A868C 对其他前列腺素受体 (IP、EP1、EP2、TP 和 FP) 没有影响。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Caldwell, A.G., Harris, C.J., Stepney, R., et al.Hydantoin prostaglandin analogues, potent and selective inhibitors of platelet aggregationJ. Chem. Soc. Chem. Comm.,561-562(1979)
Trist, D.G., Collins, B.A., Wood, J., et al.The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclaseBr. J. Pharmacol.96(2),301-306(1989)
Bhattacherjee, P., Jacobs, N., Coca-Prados, M., et al.Identification of prostanoid receptors in rabbit non-pigmented ciliary epithelial cellsExp. Eye Res.62(5),491-498(1996)
Giles, H., Leff, P., Bolofo, M.L., et al.The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonistBr. J. Pharmacol.96(2),291-300(1989)
