CRANAD-2
Cat. No.：YN380325
| 产品名称: | CRANAD-2 |
| CAS No.: | 1193447-34-5 |
| Chemical Name: | (T-4)-[(1E,6E)-1,7-bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoro-boron |
| Synonyms: | CRANAD 2;CRANAD-2;(T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-?O3,?O5]difluoroboron |
| 分子量: | 410.3 |
| 分子式: | C23H25BF2N2O2 |
| SMILES: | [F-][B+3]1([F-])[O]=C([CH-]C(/C=C/C2=CC=C(N(C)C)C=C2)=[O]1)/C=C/C3=CC=C(N(C)C)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CRANAD-2 是一种检测 Aβ 斑块的特异性近红外 (NIR) 荧光探针。CRANAD-2 可穿透血脑屏障，并对 Aβ 聚集体具有高度亲和力，其Kd值为38 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ran, C., Xu, X., Raymond, S.B., et al.Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-β depositsJ. Am. Chem. Soc.131(42),15257-15261(2009)
Ran, C., Zhao, W., Moir, R.D., et al.Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta speciesPLoS One6(4),e19362(2011)
