Macitentan-d
Cat. No.：YN322211
| 产品名称: | Macitentan-d |
| CAS No.: | 1258428-05-5 |
| Chemical Name: | N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy-1,1,2,2-d4]-4-pyrimidinyl]-N'-propyl-sulfamide |
| Synonyms: | ACT-064992-d |
| 分子量: | 592.29838 |
| 分子式: | C19H16Br2D4N6O4S |
| SMILES: | BrC1=CC=C(C2=C(OC([2H])([2H])C([2H])([2H])OC3=NC=C(Br)C=N3)N=CN=C2NS(NCCC)(=O)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Macitentan-d4是一种 Macitentan 氘代物。Macitentan (ACT-064992) 是有口服活性，非多肽ETA和ETB(内皮素受体)双拮抗剂。Macitentan 有用于特发性肺纤维化和肺动脉高压的潜力。。 |
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Iglarz, M., Binkert, C., Morrison, K., et al.Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonistJ. Pharmacol. Exp. Ther.327(3),736-745(2008)
Lefaucheur, C., Loupy, A., and Zeevi, A.Complement-binding anti-HLA antibodies and kidney transplantationN. Engl. J. Med.370(1),85-86(2014)
