MFZ 10-7
Cat. No.：YN322212
| 产品名称: | MFZ 10-7 |
| CAS No.: | 1259372-69-4 |
| Chemical Name: | (1R,2S)-rel-2-[[(3,5-dichlorophenyl)amino]carbonyl]-cyclohexanecarboxylic acid, monosodium salt |
| Synonyms: | |
| 分子量: | 338.16107 |
| 分子式: | C14H14Cl2NO3 • Na |
| SMILES: | ClC1=CC(NC([C@H]2[C@@H](C([O-])=O)CCCC2)=O)=CC(Cl)=C1.[Na+] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VU0155041 sodium 是一种有效，选择性的mGluR4混合变构激动剂/正变构调节剂 (PAM)，对人和大鼠mGluR4的EC50值分别为 798 nM 和 693 nM。VU0155041 sodium 有潜力用于帕金森病的研究。 |
| IC50和靶点: | [{name:"mGluR4:693 nM (EC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Niswender, C.M., Johnson, K.A., Weaver, C.D., et al.Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4Mol. Pharmacol.74(5),1345-1358(2008)
Becker, J.A., Clesse, D., Spiegelhalter, C., et al.Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activityNeuropsychopharmacology39(9),2049-2060(2014)
Duvoisin, R.M., Villasana, L., Davis, M.J., et al.Opposing roles of mGluR8 in measures of anxiety involving non-social and social challengesBehav. Brain Res.221(1),50-54(2011)
