Ganirelix acetate
Cat. No.：YN322221
| 产品名称: | Ganirelix acetate |
| CAS No.: | 129311-55-3 |
| Chemical Name: | N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[(ethylamino)(ethylimino)methyl]-D-lysyl-L-leucyl-N6-[(ethylamino)(ethylimino)methyl]-L-lysyl-L-prolyl-D-alaninamide, diacetate |
| Synonyms: | Ganirest |
| 分子量: | 1690.4 |
| 分子式: | C80H113ClN18O13 • 2C2H4O2 |
| SMILES: | O=C(N[C@H](CC1=CC=C(Cl)C=C1)C(N[C@H](CC2=CN=CC=C2)C(N[C@@H](CO)C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](CCCC/N=C(NCC)/NCC)C(N[C@@H](CC(C)C)C(N[C@@H](CCCC/N=C(NCC)/NCC)C(N4[C@H](C(N[C@H](C)C(N)=O)=O)CCC4)=O)=O)=O)=O)=O)=O)=O)[C@H](NC(C)=O)CC5=CC6=CC=CC=C6C=C5.OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ganirelix acetate (Ganirest) 是一种可注射的竞争性促性腺素释放激素 (GnRH)拮抗剂。Ganirelix acetate 可直接与内源性分子竞争受体结合，并导致雌二醇水平迅速降低。Ganirelix acetate 可用于卵巢过度刺激综合征 (OHSS) 研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Jiang, G., Stalewski, J., Galyean, R., et al.GnRH antagonists: A new generation of long acting analogues incorporating p-ureido-phenylalanines at positions 5 and 6J. Med. Chem.44(3),453-467(2001)
Brogua, P., Riviere, P.J.-M., Conn, P.M., et al.Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormone antagonist: DegarelixJ. Pharmacol. Exp. Ther.301(1),95-102(2002)
Lebovic, D.I., Mwenda, J.M., Chai, D.C., et al.PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: A prospective, randomized, placebo- and drug-controlled studyFertil Steril.88(4 Suppl),1108-1119(2007)
