CI-988
Cat. No.：YN322224
| 产品名称: | CI-988 |
| CAS No.: | 130332-27-3 |
| Chemical Name: | 4,9-Dihydro-4-[1-(methyl-d3)-4-piperidinylidene]-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one (2E)-2-Butenedioate; Ketotifen-d3 Hydrogen Fumarate; Totifen-d3; Zaditen-d3; Zaditor-d3; Zasten-d3; |
| Synonyms: | PD134308 |
| 分子量: | 614.73 |
| 分子式: | C35H42N4O6 |
| SMILES: | OC(CCC(N[C@H](C1=CC=CC=C1)CNC([C@](CC2=CNC3=C2C=CC=C3)(C)NC(OC4[C@H]5C[C@H](C6)C[C@@H]4C[C@H]6C5)=O)=O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CI-988 (PD134308) 是一种有效、选择性和具有口服活性的CCK2R（胆囊收缩素 2 受体）拮抗剂，对小鼠皮质 CCK2 的IC50为 1.7 nM。CI-988 对 CCK2 的选择性超过 CCK1 受体的 1600 倍。CI-988 具有抗焦虑和抗肿瘤作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Drysdale, M. et al.: Bioorg. Med. Chem. Lett., 2, 45 (1992)
Moody, T.W. et al.: J. Pharmacol. Exp. Ther., 299, 1154 (2001)
