RU-505
Cat. No.：YN380333
| 产品名称: | RU-505 |
| CAS No.: | 1314206-29-5 |
| Chemical Name: | N-[2-(dimethylamino)ethyl]-2-(1,1-dimethylethyl)-7-(4-fluorophenyl)-N-(phenylmethyl)-pyrazolo[1,5-a]pyrimidine-5-carboxamide |
| Synonyms: | RU505 |
| 分子量: | 473.6 |
| 分子式: | C28H32FN5O |
| SMILES: | CC(C)(C)C1=NN(C(C2=CC=C(F)C=C2)=CC(C(N(CCN(C)C)CC3=CC=CC=C3)=O)=N4)C4=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RU-505 是一种有效的 β-淀粉样蛋白 (Aβ)-纤维蛋白原相互作用抑制剂，在荧光偏振 (FP) 和 AlphaLISA 测定中的IC50分别为 5.00 和 2.72 μM。RU-505 可透过血脑屏障。RU-505 可减少脑淀粉样血管病 (CAA)。RU-505可用于阿尔茨海默病 (AD) 的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ahn, H.J., Glickman, J.F., Poon, K.L., et al.A novel Αβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease miceJ. Exp. Med.211(6),1049-1062(2014)
