CB2 receptor agonist 2
Cat. No.：YN322230
| 产品名称: | CB2 receptor agonist 2 |
| CAS No.: | 1314230-75-5 |
| Chemical Name: | 6-(2-furanyl)-1,4-dihydro-8-methoxy-4-oxo-1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-3-quinolinecarboxamide |
| Synonyms: | |
| 分子量: | 488.6 |
| 分子式: | C30H36N2O4 |
| SMILES: | O=C(C1=CN(CCCCC)C2=C(C=C(C3=CC=CO3)C=C2OC)C1=O)N[C@@]45CC6C[C@H](C5)C[C@H](C4)C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CB2receptor agonist 2 是CB2受体的有效和选择性激动剂。对CB2的Ki为 8.5 nM。CB2receptor agonist 2 对CB2具有高亲和力和选择性。 |
| IC50和靶点: | [{name:"CB2:8.5 nM (Ki)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Guindon, J., and Hohmann, A.G.Cannabinoid CB2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic painBr. J. Pharmacol.153(2),319-334(2008)
Idris, A.I., van't Hof, R.J., Greig, I.R., et al.Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptorsNat. Med.Advance Online Publication,1-6(2005)
Pasquini, S., De Rosa, M., Pedani, V., et al.Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in miceJ. Med. Chem.54(15),5444-5453(2011)
