BIMU 8
Cat. No.：YN322235
| 产品名称: | BIMU 8 |
| CAS No.: | 134296-40-5 |
| Chemical Name: | 2,3-dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide, monohydrochloride |
| Synonyms: | |
| 分子量: | 378.89614 |
| 分子式: | C19H26N4O2 • HCl |
| SMILES: | O=C(N1C(N(C(C)C)C2=C1C=CC=C2)=O)N[C@@H]3C[C@@H]4CC[C@@H](N4C)C3.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BIMU 8 是一种有效的选择性5-HT4激动剂，对野生型5HT4受体、T3.36A和W6.48A突变型 5-HT4 受体的EC50为 18 nM、77 nM 和 540 nM。 |
| IC50和靶点: | [{name:"5-HT4 Receptor:18 nM (EC50)"},{name: "T3.36A-5-HT4:77 nM (EC50)"},{name: "W6.48A-5-HT4:540 nM (EC50)"}] |
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| Solvent & Solubility: |
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Dumuis, A., Sebben, M., Monferini, E., et al.Azabicycloalkyl benzimidazolone derivatives as a novel class of potent agonists at the 5-HT4 receptor positively coupled to adenylate cyclase in brainNaunyn Schmiedebergs Arch. Pharmacol.343(3),245-251(1991)
Consolo, S., Arnaboldi, S., Giorgi, S., et al.5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortexNeuroreport5(10),1230-1232(1994)
Mine, Y., Yoshikawa, T., Oku, S., et al.Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitroJ. Pharmacol. Exp. Ther.283(3),1000-1008(1997)
Ghelardini, C., Galeotti, N., Casamenti, F., et al.Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8Life Sci.58(25),2297-2309(1996)
