SB 258741 hydrochloride
Cat. No.：YN322330
| 产品名称: | SB 258741 hydrochloride |
| CAS No.: | 172895-39-5 |
| Chemical Name: | 1-[(2-chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole, monohydrochloride |
| Synonyms: | |
| 分子量: | 407.3 |
| 分子式: | C21H23ClN2O2 • HCl |
| SMILES: | ClC1=C(OC)C(OC)=CC=C1CC(NCC2)C3=C2C4=CC(C)=CC=C4N3.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY266097 hydrochloride 是一种选择性的5-HT2B受体拮抗剂，对5-HT2A、5-HT2B、5-HT2C的pKi分别为 7.7、9.8 和 7.6。5-HT2B 受体阻断有助于抑郁症的研究。 |
| IC50和靶点: | [{name:"5-HT2B Receptor:9.8 (pKi)"},{name: "5-HT2A Receptor:7.7 (pKi)"},{name: "5-HT2C Receptor:7.6 (pKi)"}] |
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Auclair, A.L., Cathala, A., Sarrazin, F., et al.The central serotonin2B receptor: A new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activityJ. Neurochem.115(5),1323-1332(2010)
Audia, J.E., Evrard, D.A., Murdoch, G.R., et al.Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundusJ. Med. Chem.39(14),2773-2780(1996)
Pineda-Farias, J.B., Velázquez-Lagunas, I., Barragán-Iglesias, P., et al.5-HT2B receptor antagonists reduce nerve injury-induced tactile allodynia and expression of 5-HT2B receptorsDrug Dev. Res.76(1),31-39(2015)
Devroye, C., Cathala, A., Di Marco, B., et al.Central serotonin2B receptor blockade inhibits cocaine-induced hyperlocomotion independently of changes of subcortical dopamine outflowNeuropharmacology97,329-337(2015)
