Lu AA33810
Cat. No.：YN322459
CAS No. ：304008-29-5
规格
价格(RMB)
库存
| 产品名称: | Lu AA33810 |
| CAS No.: | 304008-29-5 |
| Chemical Name: | N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide |
| Synonyms: | |
| 分子量: | 423.61882 |
| 分子式: | C19H25N3O2S3 |
| SMILES: | CS(NC[C@@H](CC1)CC[C@H]1NC2=NC3=C(S2)CCSC4=CC=CC=C34)(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lu AA33810 是一种有效的、选择性的神经肽 Y5 受体拮抗剂，对人类受体的 Ki为 1.5 nM。Lu AA33810 表现出抗焦虑和抗抑郁样的作用。 |
| IC50和靶点: | [{name:"hY5 receptor:1.5 nM (Ki)"}] |
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| Clinical Trial: | |
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Walker, M.W., Wolinsky, T.D., Jubian, V., et al.The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivityJ. Pharmacol. Exp. Ther.328(3),900-911(2009)
