Talinolol
Cat. No.：YN322560
CAS No. ：57460-41-0
规格
价格(RMB)
库存
| 产品名称: | Talinolol |
| CAS No.: | 57460-41-0 |
| Chemical Name: | N-cyclohexyl-N'-[4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-urea |
| Synonyms: | Cordanum |
| 分子量: | 363.5 |
| 分子式: | C20H33N3O3 |
| SMILES: | O=C(NC1CCCCC1)NC2=CC=C(OCC(O)CNC(C)(C)C)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Talinolol (Cordanum) 是一种长效、心脏选择性的 β1-肾上腺素能受体阻滞剂。Talinolol 具有心脏保护和抗高血压活性。Talinolol 也是众所周知且经常使用的 P-糖蛋白 (P-gp) 活性探针底物。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Abmann, I.The actions of talinolol, a β1-selectiveβblocker, in cardiac arrhythmia and acute myocardial infarctionCurr. Med. Res. Opin.13(6),325-342(1995)
Trausch, B., Oertel, R., Richter, K., et al.Disposition and bioavailability of the β1-adrenoceptor antagonist talinolol in manBiopharm. Drug Dispos.16(5),403-414(1995)
Zschiesche, M., Lemma, G.L., Klebingat, K.J., et al.Stereoselective disposition of talinolol in manJ. Pharm. Sci.91(2),303-311(2002)
Schwarz, U.I., Seemann, D., Oertel, R., et al.Grapefruit juice ingestion significantly reduces talinolol bioavailabilityClin. Pharmacol. Ther.77(4),291-301(2005)
