CAY10471
Cat. No.：YN322578
| 产品名称: | CAY10471 |
| CAS No.: | 627865-18-3 |
| Chemical Name: | (+)-3-[[(4-fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9H-carbazole-9-acetic acid |
| Synonyms: | TM30089 |
| 分子量: | 416.5 |
| 分子式: | C21H21FN2O4S |
| SMILES: | CN(S(C1=CC=C(F)C=C1)(=O)=O)C(CC2)CC3=C2N(CC(O)=O)C4=CC=CC=C43 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CAY10471 (TM30089) 是一种强效、选择性和具有口服活性的前列腺素 D2 受体CRTH拮抗剂。CAY10471 在动物模型中，减缓小管间质纤维化和慢性接触性超敏反应 (CHS) 的进程。 |
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Sugimoto, H., Shichijo, M., Iino, T., et al.An orally bioavailable small molecule antagonist of CRTH2, Ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitroJ. Pharmacol. Exp. Ther.305(1),347-352(2003)
McKenniff, M.G., Norman, P., Cuthbert, N.J., et al.BAY u3405, a potent and selective thromboxane A2 receptor antagonist on airway smooth muscle in vitroBr. J. Pharmacol.104(3),585-590(1991)
Ulven, T., and Kostenis, E.Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonistJ. Med. Chem.48(4),897-900(2005)
