JNJ-10397049
Cat. No.：YN322616
CAS No. ：708275-58-5
| 产品名称: | JNJ-10397049 |
| CAS No.: | 708275-58-5 |
| Chemical Name: | N-(2,4-dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea |
| Synonyms: | |
| 分子量: | 484.2 |
| 分子式: | C19H20Br2N2O3 |
| SMILES: | BrC1=CC(Br)=C(NC(N[C@@H]2[C@H](C3=CC=CC=C3)OC(C)(C)OC2)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-10397049 是有效的、选择性的orexin 2 受体(OX2R)的拮抗剂，其pKi值为 8.3。JNJ-10397049 对OX2R 的活性是 OX1R 的600 倍。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
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Faedo, S., Perdonà, E., Antolini, M., et al.Functional and binding kinetic studies make a distinction between OX1 and OX2 orexin receptor antagonistsEur. J. Pharmacol.692(1-3),1-9(2012)
Tran, D.T., Bonaventure, P., Hack, M., et al.Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonistsEur. J. Pharmacol.667(1-3),120-128(2011)
Gozzi, A., Turrini, G., Piccoli, L., et al.Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonistsPLoS One6(1),e16406(2011)
