Calindol hydrochloride
Cat. No.：YN322624
CAS No. ：729610-18-8
| 产品名称: | Calindol hydrochloride |
| CAS No.: | 729610-18-8 |
| Chemical Name: | N-[(1R)-1-(1-naphthalenyl)ethyl]-1H-indole-2-methanamine, monohydrochloride |
| Synonyms: | |
| 分子量: | 336.9 |
| 分子式: | C21H20N2 • HCl |
| SMILES: | C[C@H](C1=C(C=CC=C2)C2=CC=C1)NCC3=CC4=CC=CC=C4N3.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Calindol hydrochloride 是拟钙钙敏感受体 (CaSR) 的正变构调节剂 (PAM)，EC50为 132 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
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| Solvent & Solubility: |
Kessler, A., Faure, H., Petrel, C., et al.N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: Development of calindol as a new calcimimetic acting at the calcium sensing receptorBioorg. Med. Chem. Lett.14(12),3345-3349(2004)
Ma, J.N., Owens, M., Gustafsson, M., et al.Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptorJ. Pharmacol. Exp. Ther.337(1),275-284(2011)
Petrel, C., Kessler, A., Dauban, P., et al.Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domainJ. Biol. Chem.279(18),18990-18997(2004)
Ray, K., Tisdale, J., Dodd, R.H., et al.Calindol, a positive allosteric modulator of the human Ca2+ receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca2+J. Biol. Chem.280(44),37013-37020(2005)
Weston, A.H., Absi, M., Ward, D.T., et al.Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: Studies with calindol and Calhex 231Circ. Res.97(4),391-398(2005)
