ML-184
Cat. No.：YN322642
CAS No. ：794572-10-4
| 产品名称: | ML-184 |
| CAS No.: | 794572-10-4 |
| Chemical Name: | 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)-benzenesulfonamide |
| Synonyms: | CID2440433 |
| 分子量: | 470.6 |
| 分子式: | C25H34N4O3S |
| SMILES: | CC1=CC=CC(N2CCN(C(C3=CC(S(N(C)C)(=O)=O)=CC=C3N4CCCC4)=O)CC2)=C1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML-184 (CID244033) 是一种选择性的GPR55激动剂，其 EC50为 250 nM，对GPR55的选择性是 GPR35、CB1 和CB2的 100 倍以上。ML-184 通过激活GPR55诱导 ERK1/2 磷酸化和 PKCβII 向质膜移位。ML-184 (CID2440433) 在体外增加神经干细胞的增殖并促进神经元分化。 |
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Ryberg, E., Larsson, N., Sjögren, S., et al.The orphan receptor GPR55 is a novel cannabinoid receptorBr. J. Pharmacol.152(7),1092-1101(2007)
Oka, S., Nakajima, K., Yamashita, A., et al.Identification of GPR55 as a lysophosphatidylinositol receptorBiochem. Biophys. Res. Commun.362(4),928-934(2007)
Kotsikorou, E., Madrigal, K.E., Hurst, D.P., et al.Identification of the GPR55 agonist binding site using a novel set of high potency GPR55 selective ligandsBiochemistry50(25),5633-5647(2011)
