Ramelteon metabolite M-II
Cat. No.：YN322690
CAS No. ：896736-21-3
规格
价格(RMB)
库存
| 产品名称: | Ramelteon metabolite M-II |
| CAS No.: | 896736-21-3 |
| Chemical Name: | 2-hydroxy-N-[2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]-propanamide |
| Synonyms: | |
| 分子量: | 275.34288 |
| 分子式: | C16H21NO3 |
| SMILES: | CC(O)C(NCC[C@H]1C2=C(CC1)C=CC3=C2CCO3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ramelteon metabolite M-II 是雷美替胺 (Ramelteon) 的主要代谢物，其对人褪黑素受体 1 和 2 的 IC50值分别为 208 pM 和 1470 pM。雷美替胺是褪黑素受体 (melatonin) 的选择性激动剂。 |
| IC50和靶点: | |
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Nishiyama, K., Nishikawa, H., Kato, K., et al.Pharmacological characterization of M-II, the major human metabolite of ramelteonPharmacology93(3-4),197-201(2014)
Nishiyama, K., and Hirai, K.In vitro comparison of duration of action of melatonin agonists on melatonin MT1 receptor: Possible link between duration of action and dissociation rate from receptorEur. J. Pharmacol.757,42-52(2015)
