GNF-7
Cat. No.：YN440125
CAS No. ：839706-07-9
规格
价格(RMB)
库存
| 产品名称: | GNF-7 |
| CAS No.: | 839706-07-9 |
| Chemical Name: | N-[3-[1,4-dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-benzamide |
| Synonyms: | GNF7 |
| 分子量: | 547.53 |
| 分子式: | C₂₈H₂₄F₃N₇O₂ |
| SMILES: | O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(C)N=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNF-7 是一种多重激酶抑制剂。GNF-7 是Bcr-Abl的抑制剂，对 Bcr-AblWT和 Bcr-AblT315I作用的IC50值分别为 133 nM 和 61 nM。GNF-7 对ACK1和GCK也具有抑制活性，IC50分别为 25 nM 和 8 nM。GNF-7 可用于血液恶性肿瘤的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Cho, H., Shin, I., Ju, E., et al.First SAR study for overriding NRAS mutant driven acute myeloid leukemiaJ. Med. Chem.61(18),8353-8373(2018)
Choi, H.G., Ren, P., Adrian, F., et al.A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-AblJ. Med. Chem.53(15),5439-5448(2010)
