5-Iodotubercidin
Cat. No.：YN1441159
CAS No. ：24386-93-4
| 产品名称: | 5-Iodotubercidin |
| CAS No.: | 24386-93-4 |
| Chemical Name: | 5-iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Synonyms: | NSC 113939; 5-ITu |
| 分子量: | 392.15 |
| 分子式: | C₁₁H₁₃IN₄O₄ |
| SMILES: | NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=C2I)=NC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 5-Iodotubercidin (NSC 113939)，一种 ATP 类似物，是一种有效的腺苷激酶 (adenosine kinase) 抑制剂，IC50值为 26 nM。5-Iodotubercidin (NSC 113939) 通过激活磷酸化酶和糖原合成酶，在离体肝细胞中启动糖原合成。5-Iodotubercidin (NSC 113939) 也抑制 CK1、胰岛素受体酪氨酸激酶、磷酸化酶激酶、PKA、CK2、PKC 和 Haspin 抑制剂。 |
| IC50和靶点: | |
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Ugarkar, B.G., DaRe, J.M., Kopcho, J.J., et al.Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analoguesJ. Med. Chem.43(15),2883-2893(2000)
Massillon, D., Stalmans, W., van de Werve, G., et al.Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitorBiochem. J.299,123-128(1994)
Zhao, J., Liu, Q., Yi, D., et al.5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesisAntiviral Res.198,105254(2022)
García-Villafranca, J., and Castro, J.Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylaseBiochem. Pharmacol.63,1997-2000(2002)
