Myriocin
Cat. No.：YN251717
CAS No. ：35891-70-4
| 产品名称: | Myriocin |
| CAS No.: | 35891-70-4 |
| Chemical Name: | 2S-amino-3R,4R-dihydroxy-2-(hydroxymethyl)-14-oxo-6E-eicosenoic acid |
| Synonyms: | 多球壳菌素 |
| 分子量: | 401.54 |
| 分子式: | C₂₁H₃₉NO₆ |
| SMILES: | CCCCCCC(CCCCCC/C=C/C[C@@H](O)[C@H](O)[C@](CO)(N)C(O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Myriocin 是一种从Myriococcum albomyces,Isaria sinclairi和Mycelia sterilia中分离的真菌代谢产物，是一种有效的丝氨酸-棕榈酰转移酶 (serine-palmitoyl-transferase)抑制剂，是鞘脂从头合成的关键。Myriocin 强烈抑制亚基因组 HCV-1b 复制子和基因型 2a 感染性 HCV 的 JFH-1 株的复制，抑制 HCV 感染的IC50为 3.5 μg/mL。 |
| IC50和靶点: | |
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Fujita, T., Inoue, K., Yamamoto, S., et al.Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metaboliteJ. Antibiot. (Tokyo)47 (2),208-215(1994)
Miyake, Y., Kozutsumi, Y., Nakamura, S., et al.Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocinBiochem. Biophys. Res. Commun.211(2),396-403(1995)
Hidari, K.I.P.J., Ichikawa, S., Fujita, T., et al.Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cellsJ. Biol. Chem.271(24),14636-14641(1996)
Nakamura, S., Kozutsumi, Y., Sun, Y., et al.Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2J. Biol. Chem.271(3),1255-1257(1996)
Umehara, T., Sudoh, M., Yasui, F., et al.Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse modelBiochem. Biophys. Res. Commun.346(1),67-73(2006)
