GRL-0496
Cat. No.：YN251990
CAS No. ：1087243-14-8
规格
价格(RMB)
库存
| 产品名称: | GRL-0496 |
| CAS No.: | 1087243-14-8 |
| Chemical Name: | 1H-indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester |
| Synonyms: | |
| 分子量: | 272.68624 |
| 分子式: | C14H9ClN2O2 |
| SMILES: | O=C(C1=C2C=CNC2=CC=C1)OC3=CN=CC(Cl)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GRL-0496 是一种有效的氯吡啶酯衍生的SARS-CoV3CLpro抑制剂，IC50值为 30 nM。GRL-0496 显示出最佳的SARS-CoV抗病毒活性，EC50值为 6.9 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ghosh, A.K., Gong, G., Grum-Tokars, V., et al.Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitorsBioorg. Med. Chem. Lett.18(20),5684-5688(2008)
Cao, W., Cho, C.-C.D., Geng, Z.Z., et al.Evaluation of SARS-CoV-2 main protease inhibitors using a novel cell-based assayACS Cent. Sci.8(2),192-204(2022)
