Luisol A
Cat. No.：YN251991
CAS No. ：1094451-90-7
| 产品名称: | Luisol A |
| CAS No.: | 1094451-90-7 |
| Chemical Name: | 3,4,5-trihydr3,4,5-trihydroxy-benzoic acid 1,1'-(1,3-naphthalenediyl) ester |
| Synonyms: | G28UCM |
| 分子量: | 464.4 |
| 分子式: | C24H16O10 |
| SMILES: | OC1=C(O)C(O)=CC(C(OC2=CC(C=CC=C3)=C3C(OC(C4=CC(O)=C(O)C(O)=C4)=O)=C2)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UCM05 (G28UCM) 是一种有效的脂肪酸合酶 (FASN) 抑制剂，对 HER2+ 乳腺癌具有作用活性，且在抗 HER2 耐药细胞系中具有活性。UCM05 是一种丝状温度敏感蛋白 Z (FtsZ) 抑制剂，可抑制革兰氏阳性菌B. subtilis生长，MIC 值为 100 μM，但对革兰氏阴性菌E. coli缺乏活性。 |
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Turrado, C., Puig, T., García-Cárceles, J., et al.New synthetic inhibitors of fatty acid synthase with anticancer activityJ. Med. Chem.55(11),5013-5023(2012)
Puig, T., Aguilar, H., Cufi, S., et al.A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell linesBreast Cancer Res.13(6),(2011)
Ruiz-Avila, L.B., Huecas, S., Artola, M., et al.Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZACS Chem. Biol.8(9),2072-2083(2013)
