Niraparib
Cat. No.：YN270067
CAS No. ：1038915-60-4
| 产品名称: | Niraparib |
| CAS No.: | 1038915-60-4 |
| Chemical Name: | 2-[4-(3S)-3-Piperidinylphenyl]-2H-indazole-7-carboxamide; MK-4827 |
| Synonyms: | 尼拉帕尼; MK-4827 |
| 分子量: | 320.39 |
| 分子式: | C₁₉H₂₀N₄O |
| SMILES: | NC(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C21)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Niraparib (MK-4827) 是高效的，具有生物口服利用度的PARP1和PARP2抑制剂，IC50分别为 3.8 nM 和 2.1 nM。Niraparib 抑制 DNA 损伤修复，诱导凋亡 (apoptosis) 并具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"PARP-2:2.1 nM (IC50)"},{name: "PARP-1:3.8 nM (IC50)"},{name: "V-PARP:330 nM (IC50)"},{name: "TANK-1:570 nM (IC50)"},{name: "PARP-3:1300 nM (IC50)"}] |
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| In Vivo: | |
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| Solvent & Solubility: |
Jones, P., et al.: J. Med. Chem., 52, 7170 (2009)
Giannini, G., et al.: Bioorg. Med. Chem. Lett., 24, 462 (2014)
