Ro 08-2750
Cat. No.：YN270080
CAS No. ：37854-59-4
| 产品名称: | Ro 08-2750 |
| CAS No.: | 37854-59-4 |
| Chemical Name: | 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo-benzo[g]pteridine-8-carboxaldehyde |
| Synonyms: | Ro 082750 |
| 分子量: | 270.24 |
| 分子式: | C₁₃H₁₀N₄O₃ |
| SMILES: | O=CC1=C(C)C=C2N=C3C(NC(N=C3N(C)C2=C1)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ro 08-2750 是一种非肽、可逆的NGF抑制剂，能直接结合 NGF，IC50值为 ~ 1 µM。Ro 08-2750 能抑制 NGF 结合 p75NTR的优于 TRKA。Ro 08-2750 是选择性的MSI RNA 结合抑制剂，其作用的IC50值为 2.7 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Niederhauser, O., Mangold, M., Schubenel, R., et al.NGF ligand alters NGF signaling via p75NTR and trkAJ. Neurosci. Res.61(3),263-272(2000)
Li, B., Cai, S., Zhao, Y., et al.Nerve growth factor modulates the tumor cells migration in ovarian cancer through the WNT/β-catenin pathwayOncotarget7(49),81026-81048(2016)
