ZZW-115 hydrochloride
Cat. No.：YN270107
CAS No. ：10122-45-9
规格
价格(RMB)
库存
| 产品名称: | ZZW-115 hydrochloride |
| CAS No.: | 10122-45-9 |
| Chemical Name: | N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanamine, trihydrochloride |
| Synonyms: | |
| 分子量: | 573.97 |
| 分子式: | C₂₄H₃₄Cl₃F₃N₄S |
| SMILES: | FC(C(C=C1N2CCCN3CCN(CCN(C)C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F.[H]Cl.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ZZW-115 hydrochloride 是一种有效的NUPR1抑制剂，Kd为 2.1 μM，通过坏死和凋亡 (apoptosis) 诱导肿瘤细胞死亡。具有抗癌活性。 |
| IC50和靶点: | |
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Santofimia-Castaño, P., Xia, Y., Lan, W., et al.Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosisJ. Clin. Invest.129(6),2500-2513(2019)
Huang, C., Santofimia-Castaño, P., Liu, X., et al.NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent mannerCell Death Discov.7(1),269(2021)
