CDK9-IN-7
Cat. No.：YN270190
CAS No. ：2369981-71-3
| 产品名称: | CDK9-IN-7 |
| CAS No.: | 2369981-71-3 |
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| 分子量: | 547.71 |
| 分子式: | C₂₉H₃₇N₇O₂S |
| SMILES: | O=C(N(C)C)C1=CC2=CN=C(NC3=CC=C(NC(CCCCCCCN=C=S)=O)C=C3)N=C2N1C4CCCC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CDK9-IN-7 (compound 21e) 是一种高效选择性的，具有口服活性的CDK9/cyclin T抑制剂 (IC50=11 nM)，与抑制其他 CDK 相比更有效 (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM)。CDK9-IN-7 具有抗癌活性并没有明显的毒性。CDK9-IN-7 诱导非小细胞肺癌 (NSCLC) 细胞凋亡，在 G2 期阻滞细胞周期，并具有抑制非小细胞肺癌干细胞特性。 |
| IC50和靶点: | [{name:"CDK9/cyclinT1:11 nM (IC50)"},{name: "CDK4/cyclin D:148 nM (IC50)"},{name: "CDK6/cyclinD:145 nM (IC50)"}] |
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