MPI-0479605
Cat. No.：YN270193
CAS No. ：1246529-32-7
| 产品名称: | MPI-0479605 |
| CAS No.: | 1246529-32-7 |
| Chemical Name: | N6-cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine |
| Synonyms: | MPI-0479605,MPI 0479605,MPI0479605 |
| 分子量: | 407.51 |
| 分子式: | C₂₂H₂₉N₇O |
| SMILES: | CC(C=C(N1CCOCC1)C=C2)=C2NC3=NC4=C(N=CN4)C(NC5CCCCC5)=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MPI-0479605 是一种有效的，选择性的，ATP 竞争性的Mps1抑制剂，IC50值为 1.8 nM。 |
| IC50和靶点: | [{name:"Mps1:1.8 nM (IC50)"},{name: "ALK:0.26 μM (IC50)"},{name: "B-RAF:3.2 μM (IC50)"},{name: "ERK2:3.9 μM (IC50)"},{name: "FAK1:2.7 μM (IC50)"},{name: "FER:0.59 μM (IC50)"},{name: "FLT3:0.08 μM (IC50)"},{name: "INSR:0.38 μM (IC50)"},{name: "JNK1:0.11 μM (IC50)"},{name: "PLK4:3.3 μM (IC50)"},{name: "STK33:1.1 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Tardif, K.D., Rogers, A., Cassiano, J., et al.Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1Mol. Cancer Ther.10(12),2267-2275(2011)
