Topotecan Hydrochloride
Cat. No.：YN270266
CAS No. ：119413-54-6
| 产品名称: | Topotecan Hydrochloride |
| CAS No.: | 119413-54-6 |
| Chemical Name: | 10-[(dimethylamino)methyl]-4S-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, monohydrochloride |
| Synonyms: | 盐酸拓扑替康; SKF 104864A Hydrochloride; NSC 609669 Hydrochloride |
| 分子量: | 457.91 |
| 分子式: | C₂₃H₂₄ClN₃O₅ |
| SMILES: | [H]Cl.O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Topotecan Hydrochloride (SKF 104864A Hydrochloride) 是具有抗癌活性的拓扑异构酶I抑制剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Rothenberg, M.L.Topoisomerase I inhibitors: Review and updateAnn. Oncol.8(9),837-855(1997)
Dancey, J., and Eisenhauer, E.A.Current perspectives on camptothecins in cancer treatmentBr. J. Cancer74(3),327-338(1996)
Schellens, J.H., Creemers, G.J., Beijnen, J.H., et al.Bioavailability and pharmacokinetics of oral topotecan: A new topoisomerase I inhibitorBr. J. Cancer73(10),1268-1271(1996)
Caceres, G., Zankina, R., Zhu, X., et al.Determination of chemotherapeutic activity in vivo by luminescent imaging of luciferase-transfected human tumorsAnticancer Drugs14(7),569-574(2003)
