CYC-116
Cat. No.：YN290064
CAS No. ：693228-63-6
| 产品名称: | CYC-116 |
| CAS No.: | 693228-63-6 |
| Chemical Name: | 4-(2-amino-4-methyl-5-thiazolyl)-N-[4-(4-morpholinyl)phenyl]-2-pyrimidinamine |
| Synonyms: | 噻氯匹定 |
| 分子量: | 368.46 |
| 分子式: | C₁₈H₂₀N₆OS |
| SMILES: | CC1=C(SC(N)=N1)C2=NC(NC3=CC=C(C=C3)N4CCOCC4)=NC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CYC-116是有效的极光激酶A和B (aurora A/B) 的抑制剂，Ki值分别为8和9 nM。 |
| IC50和靶点: | [{name:"Aurora A:8 nM (Ki)"},{name: "Aurora B:9.2 nM (Ki)"}] |
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| Solvent & Solubility: |
Wang, S., Midgley, C.A., Scaërou, F., et al.Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitorsJ. Med. Chem.53(11),4367-4378(2010)
