SNS-314
Cat. No.：YN290165
CAS No. ：1146618-41-8
| 产品名称: | SNS-314 |
| CAS No.: | 1146618-41-8 |
| Chemical Name: | N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]-urea, monomethanesulfonate |
| Synonyms: | SNS-314 |
| 分子量: | 527.04 |
| 分子式: | C₁₉H₁₉ClN₆O₄S₃ |
| SMILES: | O=C(NC1=CC=CC(Cl)=C1)NC2=NC=C(S2)CCNC3=C4C(C=CS4)=NC=N3.OS(C)(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SNS-314有效，选择性的极光激酶 (aurora) 抑制剂，对极光激酶A，B，C的IC50值分别为9，31 和6 nM。 |
| IC50和靶点: | [{name:"Aurora A:9 nM (IC50)"},{name: "Aurora B:31 nM (IC50)"},{name: "Aurora C:6 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Oslob, J.D., Romanowski, M.J., Allen, D.A., et al.Discovery of a potent and selective aurora kinase inhibitorBioorg. Med. Chem. Lett.18(17),4880-4884(2008)
Arbitrario, J.P., Belmont, B.J., Evanchik, M.J., et al.SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivoCancer Chemother. Pharmacol.65(4),707-717(2010)
