AMG 900
Cat. No.：YN290245
CAS No. ：945595-80-2
| 产品名称: | AMG 900 |
| CAS No.: | 945595-80-2 |
| Chemical Name: | N-[4-[[3-(2-amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine |
| Synonyms: | AMG900,AMG-900,莪术醇.姜黄醇 |
| 分子量: | 503.58 |
| 分子式: | C₂₈H₂₁N₇OS |
| SMILES: | CC1=CSC(C2=NN=C(C3=C2C=CC=C3)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=CC=NC(N)=N6)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AMG 900 是一种有效的选择性的pan-Aurora激酶抑制剂，作用于Aurora A，B和C，IC50分别为 5 nM，4 nM 和 1 nM。 |
| IC50和靶点: | [{name:"Aurora A:5 nM (IC50)"},{name: "Aurora B:4 nM (IC50)"},{name: "Aurora C:1 nM (IC50)"}] |
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Payton, M., Bush, T.L., Chung, G., et al.Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell linesCancer Res.70(23),9846-9854(2010)
