JNJ16259685
Cat. No.：YN320044
CAS No. ：409345-29-5
规格
价格(RMB)
库存
| 产品名称: | JNJ16259685 |
| CAS No.: | 409345-29-5 |
| Chemical Name: | (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(cis-4-methoxycyclohexyl)-methanone |
| Synonyms: | .TN.T 16259685 |
| 分子量: | 325.40 |
| 分子式: | C₂₀H₂₃NO₃ |
| SMILES: | O=C(C1=CC=C2N=C3C(CCCO3)=CC2=C1)[C@H]4CC[C@@H](OC)CC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ16259685 是一种选择性的mGlu1 receptor拮抗剂，能够浓度依赖性地抑制 mGlu1 的突触的活化，IC50值为 19 nM。 |
| IC50和靶点: | [{name:"mGluR1:19 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lavreysen, H., Wouters, R., Bischoff, F., et al.JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonistNeuropharmacology47(7),961-972(2004)
Steckler, T., Lavreysen, H., Oliveira, A.M., et al.Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression testPsychopharmacology (Berl.)179(1),198-206(2005)
