Combretastatin A-1
Cat. No.：YN290575
CAS No. ：109971-63-3
| 产品名称: | Combretastatin A-1 |
| CAS No.: | 109971-63-3 |
| Chemical Name: | 3-methoxy-6-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-1,2-benzenediol |
| Synonyms: | 康普瑞汀A-1 |
| 分子量: | 332.4 |
| 分子式: | C18H20O6 |
| SMILES: | COC(C(O)=C1O)=CC=C1/C=C\C2=CC(OC)=C(OC)C(OC)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Combretastatin A-1 是一种微管聚合抑制剂，可与微管蛋白的秋水仙碱结合位点结合。Combretastatin A-1 通过微管蛋白解聚介导的AKT失活抑制Wnt/β-catenin通路。Combretastatin A-1 具有抗肿瘤和抗血管作用。 |
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Pettit, G.R., Singh, S.B., Niven, M.L., et al.Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrumJ. Nat. Prod.50(1),119-131(1987)
Mao, J., Wang, D., Wang, Z., et al.Combretastatin A-1 phosphate, a microtubule inhibitor, acts on both hepatocellular carcinoma cells and tumor-associated macrophages by inhibiting the Wnt/β-catenin pathwayCancer Lett.380(1),134-143(2016)
Staflin, K., Järnum, S., Hua, J., et al.Combretastatin A-1 phosphate potentiates the antitumor activity of carboplatin and paclitaxel in a severe combined immunodeficiency disease (SCID) mouse model of human ovarian carcinomaInt. J. Gynecol. Cancer16(4),1557-1564(2006)
Shnyder, S.D., Cooper, P.A., Pettit, G.R., et al.Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma modelAnticancer Res.23(2B),1619-1623(2003)
Holwell, S.E., Cooper, P.A., Thompson, M.J., et al.Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-1 phosphateAnticancer Res.22(6C),3933-3940(2002)
