Temozolomide acid
Cat. No.：YN290579
| 产品名称: | Temozolomide acid |
| CAS No.: | 113942-30-6 |
| Chemical Name: | 3,4-dihydro-3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid |
| Synonyms: | Temozolomide Acid; TMZA |
| 分子量: | 195.1358 |
| 分子式: | C6H5N5O3 |
| SMILES: | O=C(C(N=CN12)=C2N=NN(C)C1=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Temozolomide acid 是 Temozolomide 的羧酸衍生物。Temozolomide 是一种 DNA 烷基化剂，使 DNA 的鸟嘌呤和腺嘌呤碱基甲基化，导致 DNA 双链断裂，细胞周期阻滞，最终导致细胞死亡。Temozolomide acid 具有类似于其母体化合物 Temozolomide 类似的抗癌活性。 |
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Tsang, L.L.H., Farmer, P.B., Gescher, A., et al.Characterisation of urinary metabolites of temozolomide in humans and mice and evaluation of their cytotoxicityCancer Chemother. Pharmacol.26(6),429-436(1990)
Liu, D., Yang, J.-G., Cheng, J., et al.Synthesis and antitumor activity of 3-methyl-4-oxo-3,4-dihydroimidazo [5,1-d][1,2,3,5]tetrazine-8-carboxylates and -carboxamidesMolecules15(12),9427-9437(2010)
