RKI-1313
Cat. No.：YN290609
CAS No. ：1342276-76-9
| 产品名称: | RKI-1313 |
| CAS No.: | 1342276-76-9 |
| Chemical Name: | N-[(3-methoxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-urea |
| Synonyms: | PKI1313,PKI 1313 |
| 分子量: | 340.4 |
| 分子式: | C17H16N4O2S |
| SMILES: | O=C(NC1=NC(C2=CC=NC=C2)=CS1)NCC3=CC=CC(OC)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RKI-1313 是一种ROCK抑制剂，对ROCK1 和ROCK2 的IC50s 分别为 34、8 µM。RKI-1313 对ROCK底物的磷酸化水平、迁移、侵袭或不依赖锚定的生长显示较小的影响。 |
| IC50和靶点: | [{name:"ROCK1:34 μM (IC50)"},{name: "ROCK2:8 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Patel, R.A., Forinash, K.D., Pireddu, R., et al.RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and anti-tumor activities in breast cancerCancer Res.72(19),5025-5034(2012)
