VUF10166
Cat. No.：YN1730136
CAS No. ：155584-74-0
规格
价格(RMB)
库存
| 产品名称: | VUF10166 |
| CAS No.: | 155584-74-0 |
| Chemical Name: | 2-chloro-3-(4-methyl-1-piperazinyl)-quinoxaline |
| Synonyms: | |
| 分子量: | 262.73786 |
| 分子式: | C13H15ClN4 |
| SMILES: | ClC1=C(N2CCN(CC2)C)N=C3C=CC=CC3=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VUF10166 是一种有效的高亲和力的5-HT3受体拮抗剂，其Ki值分别为 0.04 nM (5-HT3A) 和 22 nM (5-HT3AB)。在纳米摩尔浓度下，VUF10166 对 5-HT3A 和 5-HT3AB 受体的 5-HT 诱导的反应具有抑制作用。在5-HT3受体下，较高浓度的 VUF10166 也可作为部分激动剂，其EC50为 5.2 μM。 |
| IC50和靶点: | [{name:"5-HT3A Receptor:0.04 nM (Ki)"},{name: "5-HT 3 AB:22 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Thompson, A.J., Verheij, M.H.P., de Esch, I.J.P., et al.VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptorsJ. Pharmacol. Exp. Ther.341(2),350-359(2012)
