Tankyrase-IN-2
Cat. No.：YN290644
CAS No. ：1588870-36-3
| 产品名称: | Tankyrase-IN-2 |
| CAS No.: | 1588870-36-3 |
| Chemical Name: | 6,8-difluoro-2-[4-(1-hydroxy-1-methylethyl)phenyl]-4(3H)-quinazolinone |
| Synonyms: | |
| 分子量: | 316.3021464 |
| 分子式: | C17H14F2N2O2 |
| SMILES: | CC(C)(O)C1=CC=C(C2=NC(C(C=C(F)C=C3F)=C3N2)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tankyrase-IN-2 (compound 5k) 是一种有效选择性的tankyrase抑制剂 (对 TNKS1, TNKS2,PARP1的IC50值分别为 10 nM, 7 nM, 710 nM)，具有良好的理化特性和药动学特性，可调节结直肠癌异种移植模型中Wnt通路的活性。 |
| IC50和靶点: | |
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Buchstaller, H.-P., Anlauf, U., Dorsch, D., et al.Discovery and optimization of 2-arylquinazolin-4-ones into a potent and selective tankyrase inhibitor modulating Wnt pathway activityJ. Med. Chem.62(17),7897-7909(2019)
