Lerociclib
Cat. No.：YN290652
| 产品名称: | Lerociclib |
| CAS No.: | 1628256-23-4 |
| Chemical Name: | |
| Synonyms: | G1T38 |
| 分子量: | 474.6 |
| 分子式: | C26H34N8O |
| SMILES: | C1(CNC(=O)C2N1C1C(C=2)=CN=C(NC2=NC=C(N3CCN(C(C)C)CC3)C=C2)N=1)1CCCCC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lerociclib (G1T38) 是一种有效的、CDK4/6的选择性抑制剂，其对 CDK4/CyclinD1 和 CDK6/CyclinD3 的IC50值分别为 1 nM 和 2 nM。 |
| IC50和靶点: | [{name:"cdk2/cyclin A:1.5 μM (IC50)"},{name: "CDK2/cyclinE:3.6 μM (IC50)"},{name: "Cdk4/cyclin D1:1 nM (IC50)"},{name: "cdk6/cyclin D3:2 nM (IC50)"},{name: "CDK9/Cyclin T:28 nM (IC50)"},{name: "CDK5/p35:0.832 μM (IC50)"},{name: "CDK1/cyclinB1:2.4 μM (IC50)"},{name: "CDK7/Cyclin H/MAT1:2.4 μM (IC50)"},{name: "Cdk5/p25:1.2 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
