2BAct
Cat. No.：YN290689
CAS No. ：2143542-28-1
规格
价格(RMB)
库存
| 产品名称: | 2BAct |
| CAS No.: | 2143542-28-1 |
| Chemical Name: | N-[3-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]bicyclo[1.1.1]pent-1-yl]-5-(difluoromethyl)-2-pyrazinecarboxamide |
| Synonyms: | |
| 分子量: | 440.8034096 |
| 分子式: | C19H16ClF3N4O3 |
| SMILES: | O=C(C1=NC=C(C(F)F)N=C1)NC23CC(C2)(C3)NC(COC4=CC=C(C(F)=C4)Cl)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 2BAct 是一种具有高选择性的，具有口服活性的真核起始因子eIF2B活化剂，EC50为 33 nM。2BAct 可防止由慢性综合应激反应引起的神经系统缺陷。2BAct 可透过血脑屏障。2BAct 相对于 eIF2B 激活剂 ISRIB (HY-12495) 显示出更好的溶解度和药代动力学性质。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Wong, Y.L., LeBon, L.B., A.M., Kohlhaas, K.L., et al.eIF2B activator prevents neurological defects caused by a chronic integrated stress responseeLife8,e42949(2019)
