AES-135
Cat. No.：YN290711
CAS No. ：2361659-61-0
规格
价格(RMB)
库存
| 产品名称: | AES-135 |
| CAS No.: | 2361659-61-0 |
| Chemical Name: | |
| Synonyms: | 4-(N-(4-(tert-butyl)benzyl)-2-((4-fluoro-N-((perfluorophenyl)methyl)phenyl)sulfonamido)acetamido)-N-hydroxybenzamide;BDBM50519452;Chembl4520400;AES-135 |
| 分子量: | 693.6559 |
| 分子式: | C33H29F6N3O5S |
| SMILES: | S(C1C([H])=C([H])C(=C([H])C=1[H])F)(N(C([H])([H])C1C(=C(C(=C(C=1F)F)F)F)F)C([H])([H])C(N(C1C([H])=C([H])C(C(N([H])O[H])=O)=C([H])C=1[H])C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=O)(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AES-135 是一种基于羟肟酸的泛HDAC抑制剂，可延长胰腺癌原位小鼠模型的存活时间。AES-135 抑制 HDAC3、HDAC6、HDAC8 和HDAC11，IC50范围为190-1100 nM。 |
| IC50和靶点: | [{name:"HDAC6:190 nM (IC50)"},{name: "HDAC11:636 nM (IC50)"},{name: "HDAC3:654 nM (IC50)"},{name: "HDAC8:1100 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
